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1. Download the anesthesia central app by Unbound Medicine, 2. Tendon rupture has occurred. AU - Sanoski,Cynthia A, Class. References1 Laufs U, et al. Any forward-looking statements contained in this press release speak only as of the date hereof, and Esperion disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law. Approved earlier this year by the U.S. Food and Drug Administration (FDA) and launched at the height of the COVID-19 pandemic, NEXLETOL is the first oral, once-daily, non-statin LDL-C-lowering medicine available to indicated patients in nearly 20 years. This collection of drugs, procedures, and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and PRIME Journals. Bempedoic Acid [Internet]. ID - 110815 Trade Name(s) Nexletol; Ther. To view the entire topic, please sign in or purchase a subscription. A1 - Quiring,Courtney, PB - F.A. Class. DB - Anesthesia Central NEXLETOL is the first oral, once-daily, non-statin LDL-C lowering medicine approved in the U.S. in nearly 20 years for patients with ASCVD or HeFH. LDL-C lowering was numerically greater in females compared with males across both pools of the study: The placebo-corrected mean reduction was 27.7% for females vs. 22.1% for males (interaction p value=0.079) in the statin-intolerant pool, and 21.2% for females vs. 17.4% for males (interaction p value=0.044) in the pool of patients with atherosclerotic cardiovascular disease (ASVCD) and/or heterozygous familial hypercholesterolemia (HeFH) who were receiving background maximally tolerated statin. *Note: Esperion strives to be inclusive in our both research and our language, and we follow the language guidance outlined in “Reporting Sex, Gender, or Both in Clinical Research?” from The Journal of the American Medicine Association (JAMA). Both analyses demonstrated significant lowering of low-density lipoprotein cholesterol (LDL-C) by NEXLETOL® (bempedoic acid) Tablets by week 12 in specific subgroups, including people who cannot tolerate statins and females, compared to placebo. © 2020 GlobeNewswire, Inc. All Rights Reserved. NEXLETOL was approved by the FDA in February 2020. Select Try/Buy and follow instructions to begin your free 30-day trial, © 2000–2020 Unbound Medicine, Inc. All rights reserved, TY - ELEC Through scientific and clinical excellence, and a deep understanding of cholesterol biology, the experienced Lipid Management Team at Esperion is committed to developing new LDL-C lowering medicines that will make a substantial impact on reducing global cardiovascular disease, the leading cause of death around the world. ET - 16 The risk for gout events with NEXLETOL® (bempedoic acid) tablet was higher in patients with a prior history of gout although gout also occurred more frequently than placebo in patients treated with NEXLETOL™ (bempedoic acid) tablet who had no prior gout history. lipid-lowering agents. Forward-looking statements involve risks and uncertainties that could cause Esperion's actual results to differ significantly from those projected, including, without limitation, delays or failures in Esperion’s clinical development and commercialization plans, or approval of expanded indications, that existing cash resources may be used more quickly than anticipated, the impact of COVID-19 on our business, clinical activities and commercial development plans, and the risks detailed in Esperion's filings with the Securities and Exchange Commission. Want to see more products from Unbound Medicine. Bempedoic acid. bempedoic acid is a topic covered in the Davis's Drug Guide. Please see the full Prescribing Information for NEXLETOL by clicking here. Quiring C, Sanoski CA, Vallerand AH. The effect of NEXLETOL on cardiovascular morbidity and mortality has not been determined. T1 - bempedoic acid Class. Primary research N = 350 healthcare practitioners, 4 J Tamargo, G Rosano, T Walther, J Duarte, A Niessner, JC Kaski, C Ceconi, H Drexel, K Kjeldsen, G Savarese, C Torp-Pedersen, D Atar, BS Lewis, S Agewall, Gender differences in the effects of cardiovascular drugs, European Heart Journal - Cardiovascular Pharmacotherapy, Volume 3, Issue 3, July 2017, Pages 163–182, https://doi.org/10.1093/ehjcvp/pvw042, Contact:Kaitlyn Brosco Esperioninvestorrelations@esperion.com. bempedoic acid is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. “Women are half of the population, and nearly 10 million patients in the U.S. with high LDL-C levels are not on statins due to tolerability issues,3 yet these groups have been underrepresented in previous medical research,4” said Ashley Hall, Chief Development Officer for Esperion. For more information, please visit www.esperion.com and follow us on Twitter at www.twitter.com/EsperionInc. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 or report side effects to Esperion at 833-377-7633 (833 ESPRMED). Efficacy and Safety of Bempedoic Acid by Sex: Pooled Analyses From Phase 3 Trials. "Bempedoic Acid.". NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up-regulating the LDL receptors. Bempedoic acid, sold under the brand name Nexletolamong others, is a medication for the treatment of hypercholesterolemia(high blood cholesterollevels). You are encouraged to report negative side effects of prescription drugs to the FDA. Please Sign in with your Anesthesia Central account, Type your tag names separated by a space and hit enter. NEXLETOL is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with HeFH or established ASCVD who require additional lowering of LDL-C. The effect of NEXLETOL on cardiovascular morbidity and mortality has not yet been determined. Davis Company NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up-regulating the LDL receptors. Explore these free sample topics: Anesthesia for Vascular Surgery - Abdominal Aortic Repair, -- The first section of this topic is shown below --, Pharm. In these studies, NEXLETOL provided an average of 18% placebo-corrected LDL-C lowering when used with moderate or high-intensity statins. Presentation at the American Heart Association Virtual Scientific Sessions 2020. Pronunciation: bem-pe-doe-ik as-id. HeFH is an inherited condition that causes high levels of “bad” cholesterol called low density lipoprotein (LDL). In: * Article titles in AMA citation format should be in sentence-case, You can cancel anytime within the 30-day trial, or continue using anesthesia central Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. ER -, Quiring, Courtney, et al. DP - Unbound Medicine AU - Vallerand,April Hazard, Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2020). Please see important safety information below. November 2020. The most common (incidence ≥ 2% and greater than placebo) adverse reactions were upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia and elevated liver enzymes. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. to begin a 1-year subscription ($39.95). Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. UR - https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/110815/0/bempedoic_acid Assess uric acid levels periodically as clinically indicated. Reporting Sex, Gender, or Both in Clinical Research? 3 ZS Associates primary and secondary research, Sep-Oct 2018. Quiring C, Sanoski CA, Vallerand AH. ANN ARBOR, Mich., Nov. 13, 2020 (GLOBE NEWSWIRE) -- Esperion (NASDAQ: ESPR) today announced results of pooled data from four of the company’s Phase 3 trials were presented at the virtual American Heart Association Scientific Sessions 2020 (AHA 2020). Class.temporary class adenosine triphosphate-citrate lyase inhibitors, -- To view the remaining sections of this topic, please sign in or purchase a subscription --. BT - Davis's Drug Guide The approval of NEXLETOL was supported by a global pivotal Phase 3 LDL-C-lowering program conducted in more than 3,000 patients with ASCVD and/or HeFH. ... Nexletol; Ther. Elevations in serum uric acid have occurred. Bempedoic acid was generally well tolerated by both sexes.2. What is Nexletol? Nursing Central is an award-winning, complete mobile solution for nurses and students. 2 Goldberg AC, et al. lipid-lowering agents. Pharm. 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